   Open LOL2 and load up your game first, then press ESC to go to the the
   screen where you save,load  or chose options. Now ALT + TAB to go to
   Windows. Open the trainer and click on the life and magic button until
   you see a hex(#) sign in each of them. ALT + TAB to go back to LOL2 to
   continue with your current game.

   You must on LOL2 before you can operate the trainer!